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What is Amitriptyline?

Amitriptyline is a prescription medication that is used to treat the symptoms of depression. Amitriptyline is a tricyclic antidepressant drug and works by affecting chemicals in the brain. Amitriptyline restores the balance of chemicals in people with depression.

Make sure to always read the patient information and instructions before using this medication. Always follow your doctor’s directions.

  • This medication should be taken orally. If it is only taken once a day, take it at bedtime.
  • Do not stop taking this medication suddenly or you may suffer from unpleasant withdrawal symptoms.
  • Continue taking this medication regularly. It can take up to four weeks before your symptoms improve.


Tell your doctor and pharmacist:

  • About your drug and other allergies.
  • If you take any other prescription or over-the-counter medications.
  • Your medical history particularly of heart attacks, heart disease, liver disease, stroke, seizures, diabetes, bipolar disorder, schizophrenia, psychosis, mental illness, glaucoma or urination problems.
  • If you have taken any other antidepressants in the previous five weeks.
  • If you are pregnant or planning pregnancy.

You should also know:

  • Antidepressants may cause suicidal thoughts when first taken. Stay alert to mood or behavior changes.
  • Do not breast-feed while taking amitriptyline.
  • Amitriptyline is not approved to be taken by anyone younger than 12.
  • Do not drink alcohol while you are taking this medication. Alcohol and amitriptyline can result in dangerous or fatal side effects.
  • Amitriptyline can affect your reactions. Do not drive or operate machinery until it can be done safely.
  • This medication may make you sunburn easier. Avoid tanning beds and wear protective clothing and use sunscreen while outside.

Side Effects of Amitriptyline

Common side effects of amitriptyline include but are not limited to:

  • Decreased sex drive, impotence, or difficulty in achieving an orgasm.
  • Nausea or vomiting.
  • Breast swelling.
  • Constipation.
  • Stomach upset.
  • Itching or rash.
  • Diarrhea.
  • Unusual taste.
  • Mouth pain or black tongue.
  • Changes in weight or appetite.

Get medical help if you have any of the following side effects of amitriptyline:

  • New or worsening symptoms including mood or behavior changes, sleeping problems, depression, hyperactivity, irritation, impulsiveness, agitation, hostility, restlessness, aggressiveness, or thoughts about suicide or hurting yourself.
  • Unusual thoughts or behavior.
  • Chest pain or pressure, pounding heartbeats or fluttering in the chest.
  • Seizures.
  • Pain that spreads to the jaw or shoulder.
  • Nausea or sweating.
  • Difficult or painful urination.
  • Confusion or hallucinations.
  • Severe constipation.
  • Feeling lightheaded or like you might pass out.
  • Easy bruising or bleeding.
  • Sudden weakness or illness, chills, fever, sore throat, trouble swallowing, mouth sores, or red or swollen gums.
  • Symptoms of an allergic reaction such as difficulty breathing, hives, or swelling in your face, lips, or throat.


What should I do if I miss a dose of amitriptyline?

If you miss a dose of amitriptyline, you should take it as soon as you remember. However, if it is almost time for your next dose, then skip your missed dose.

What is the strength of amitriptyline?

Amitriptyline is available in strengths of 10mg, 25mg, 50mg and 75mg.

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