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Efudex Cream (fluorouracil) is used to treat cancerous and pre-cancerous skin growths by killing fast-growing cells and blocking the growth of abnormal cells which can cause skin condition. Fluorouracil is prescribed to treat actinic or solar keratoses which can appear as scaly and crusted lesions caused by too much exposure to sunlight over a period of years.

Make sure to always read the patient information and instructions before using this medication. Always follow your doctor’s directions.

• Apply Efudex Cream to the affected areas of your skin.
• Efudex Cream is typically applied twice a day. Try to use this medication at the same time each day.
• When treating actinic or solar keratoses, fluorouracil should be used until your lesions begin to peel off. This is usually, after two to four weeks. Your lesions may not be completely healed until up to two months after stopping applying this medication.
• When treating basal cell carcinoma, continue using Efudex Cream until all of your lesions have gone. This is typically between three and six weeks but could take up to twelve weeks.
• The affected area and surrounding areas may feel irritated and look scaly, red and swollen during the first few weeks of treatment. This is a sign that the medication is working.
• Do not apply this medication to your eyelids, eyes, nose or mouth.
• Wait two hours after applying Efudex Cream before applying sunscreen or moisturizer to the affected areas. Do not use other skin products including cosmetics, creams, lotions or medications unless directed by a doctor.

Tell your doctor and pharmacist:

• About your drug and other allergies.
• If you take any other prescription or over-the-counter medications.
• Your medical history particularly of red, irritated or infected skin, open sores and dihydropyrimidine dehydrogenase (DPD) deficiency.

You should also know:

• You must not use Efudex Ceram during pregnancy as it may harm an unborn baby. Discuss reliable forms of birth control with your doctor.
• Breast-feeding is not recommended while using this medication.
• Fluorouracil can make you more sensitive to sunlight. Wear protective clothing and sunscreen while outdoors. Avoid tanning booths and sunlamps,

Common side effects of Efudex Cream include but are not limited to:

• Skin irritation, redness, burning, pain, dryness, swelling, tenderness or changes in skin color where applied.
• Eye irritation.
• Irritability.
• Trouble sleeping.
• An unusual taste in the mouth.
• Temporary hair loss.

Get medical help if you have any of the following side effects of Efudex Cream:

• Signs of infection such as chills, fever or persistent sore throat.
• Mouth sores.
• Stomach or abdominal pain.
• Vomiting.
• Easy bruising or bleeding.
• Bloody diarrhea.
• Symptoms of an allergic reaction such as difficulty breathing, hives or swelling in your face, lips or throat.

What should I do if I miss a dose of Efudex Cream?

If you miss a dose of Efudex Cream, you should take it as soon as you remember. However, if it is almost time for your next dose, then skip your missed dose.

Can I use other skin products while using Efudex Cream?

You can use sunscreen and moisturizer on the affected areas if it applied two hours after applying Efudex Cream. Do not use other skin products on the affected areas including cosmetics, creams, lotions or medications unless directed by a doctor.