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As an anti-infective medication, Aczone Gel(dapsone topical) can help treat acne.

For optimum results, follow any dosage directions from your doctor and prescription label. And remember to avoid getting ACZONE gel anywhere near your eyes, mouth, or genitals. This medication is meant for external use only.

Once you feel ready to apply ACZONE gel, wash the skin you plan on medicating with the gel. Then, pat it all dry, and place a pea-sized amount of gel on the acne-affected skin.

When you’re done, wash your hands. And then put your medication away in a place that’s at room temperature and away from moisture and heat. But don’t freeze the medication, and make sure that the tube for the medication is tightly closed when not used.


Please note that if you’re taking benzoyl peroxide alongside Aczone gel, you may notice changes to your skin or facial hair color. But do not worry! These changes are generally expected to be temporary.

Before even taking Aczone gel, however, make sure you tell your doctor if you have or have had a glucose 6-phosphate dehydrogenase (G6PD) deficiency or methemoglobinemia. Knowing about these conditions could help your doctor see whether or not Aczone gel is safe for you.

Side Effects

If you notice any of the following side effects, call your doctor right away:

  • Severe sore throat
  • Unusual thoughts or behavior
  • Red blood cell disorder symptoms
  • Pancreas problems
  • Severe skin reaction

Do the same if you notice that you’re having an allergic reaction to Aczone gel, which could involve the following symptoms:

  • Hives
  • Breathing difficulties
  • Facial swelling

More common and less serious side effects may include dry skin, peeling skin, oily skin, and redness in the area where the gel was applied.


Does ACZONE gel interact with other drugs?

While this isn’t always the case, Aczone gel can interact negatively with medication. It just depends on the medication. For instance, if you are using sulfa drugs, Tylenol, nitroglycerin, other nitrite heart medications, or seizure medication, you could end up with the medical condition methemoglobinemia. This condition lowers the amount of oxygen in your bloodstream, potentially causing your lips, fingernails, or the inside of your mouth to turn blue or gray. If you experience this, stop taking your medication and call your doctor immediately.

Other potential negative interactions Aczone gel might have may involve prescriptions, over-the-counter medications, vitamins, and herbal products.

For more information on this, talk to your doctor.

Who can take this medication?

Right now, Aczone gel is restricted to a certain age of people. So anyone younger than 12 years of age are not allowed to use it.

Can it be taken during pregnancy?

You’re better off avoiding Aczone gel until after pregnancy. Unfortunately, it isn’t known whether the gel will harm an unborn baby. But research indicates that the gel can be absorbed into breast milk, potentially harming a nursing baby.

What should be done if there’s no visible improvement?

If you’ve taken Aczone gel for 12 weeks or longer and have seen no improvement, call your doctor. You may need to take a different medication.

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