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Angeliq is a prescription treatment that contains synthetic versions of the female hormones estrogen and progestin. It is used to treat menopause symptoms including vaginal dryness, irritation, and hot flashes.

Always follow your doctor’s instructions and use Angeliq exactly as prescribed.

  • Take Angeliq at the same time each day.
  • Swallow tablet whole. Do not crush, break, or chew.


Angeliq may increase your chances of developing uterine cancer. Inform your doctor if you have any unusual bleeding.

Angeliq may also increase your risk of ovarian cancer, stroke, dementia, and blood clots, especially in women who have high blood pressure, diabetes, high cholesterol, or who smoke. Breast cancer risk may increase with long-term use.

Grapefruit and grapefruit juice make cause side effects. Talk to your doctor before consuming grapefruit.

Do not use Angeliq if you have:

  • A bleeding disorder or unusual bleeding
  • Liver or kidney disease
  • Adrenal gland disorders
  • History of heart attack, stroke, blood clots
  • Hysterectomy or history of breast, uterine, cervical, or hormone-related cancers

Before taking Angeliq, inform your doctor if you have any of the following:

  • Heart disease
  • Thyroid disorder
  • Gallbladder disease
  • High triglycerides
  • Asthma
  • Porphyria
  • Angioedema
  • Jaundice related to pregnancy or hormone treatments
  • Lupus
  • Migraines
  • Seizures
  • Endometriosis
  • Electrolyte imbalances (calcium, potassium, sodium)

Side Effects

Common side effects of Angeliq include:

  • Nausea, diarrhea, abdominal pain
  • Breast pain
  • Headache
  • Mood changes
  • Swelling, weight gain
  • Vaginal itching or discharge

Contact your doctor if you experience these more serious side effects:

  • Abnormal bleeding
  • Heart attack symptoms – spreading chest pain or pressure, nausea, sweating
  • Jaundice
  • Pain and swelling of the stomach
  • Breast lump
  • Signs of stroke – numbness or weakness, slurred speech, severe headache, vision and balance problems
  • High potassium – tingling, weakness, nausea, irregular heartbeat, loss of movement
  • Signs of a blood clot – shortness of breath, stabbing chest pain, coughing blood, sudden vision loss, pain or warmth in legs
  • High blood pressure – headache, blurred vision, pounding in neck and ears, nosebleed, anxiety


What time of day should I use Angeliq?

You can take Angeliq at any time of day that’s convenient for you. Try to take Angeliq at the same time every day.

Will my menopause symptoms eventually go away?

Some menopause symptoms, including hot flashes, are likely to go away over time. But other symptoms like vaginal dryness may persist due to lack of estrogen. Talk to your doctor about your symptoms and how long you should take Angeliq for.

Can I buy Angeliq over the counter?

No. Angeliq is only available with a prescription at this time.

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