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Arthrotec is a prescription drug that relieves pain and inflammation due to osteoarthritis and rheumatoid arthritis. It contains an NSAID called diclofenac, and misoprostol to protect the gastrointestinal tract by reducing stomach acid.

Always follow your doctor’s instructions and use Arthrotec exactly as prescribed.

  • Take with food or milk.
  • Swallow tablet whole. Do not crush or break.


Do not use Arthrotec if you are pregnant or may become pregnant.

One of the active ingredients in Arthrotec (diclofenac) can increase you risk of fatal heart attack or stroke, especially if used long term.

Arthrotec can cause bleeding in the stomach or intestines, which can be fatal. Don’t use if you have active bleeding, and monitor closely for symptoms of GI bleeding.

Before taking Arthrotec, inform your doctor if you have any of the following:

  • Heart disease, high blood pressure, high cholesterol, diabetes
  • Stomach ulcers or bleeding
  • Asthma
  • Fluid retention
  • Porphyria
  • Liver or kidney disease

Side Effects

Common side effects of Arthrotec include:

  • Nausea, vomiting, diarrhea, constipation
  • Heartburn, indigestion, stomach pain
  • Dizziness
  • Abnormal vaginal bleeding

Contact your doctor if you experience these more serious side effects:

  • Any signs of rash
  • Swelling or weight gain
  • Signs of bleeding – coughing or vomiting blood, bloody or black stools
  • Liver problems – jaundice, dark urine, upper abdominal pain, itching, fatigue, nausea, light-colored stools
  • Anemia – light-headed, short of breath, pale skin, rapid heart rate, trouble concentrating
  • Severe skin reaction – sore throat, swollen face or tongue, burning eyes, fever, skin pain, red or purple rash with blistering
  • Kidney problems – painful urination, producing little or no urine, swollen feet and ankles, tiredness or shortness of breath


What should I avoid while taking Arthrotec?

Drinking alcohol may increase your risk of bleeding while on Arthrotec. Do not take any other NSAIDs (aspirin, ibuprofen, Celebrex, naproxen), and only use antacids that have been recommended by your doctor. Arthrotec can make you sunburn more easily, so avoid tanning beds and sun exposure without proper protection.

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