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Colchicine for Gout

Colcrys is a prescription drug used to treat flares of gout. It reduces swelling and pain by affecting the body’s response to uric acid crystals. Colcrys is also used to treat symptoms of Familial Mediterranean Fever and Behcet's syndrome.

Colcrys is not a painkiller, but it reduces the specific pain caused by gout.

How Long Does it Take for Colchicine to Work?

If taken at the first sign of pain, most patients begin to experience relief with 12 hours, and within 24 hours most of the symptoms tend to disappear. This varies on a patient-to-patient basis. Talk to your doctor about what to expect when taking Colcrys for gout.

Always follow your doctor’s instructions and use Colcrys exactly as prescribed.

• Take Colcrys with or without food.
• Avoid eating grapefruit or drinking grapefruit juice when taking Colcrys. Your doctor may also recommend following a gout diet plan.
• Ask your doctor if diet changes can help reduce the severity of gout flares.

Colcrys may damage bone marrow, causing anemia, low white cell counts, and low platelets. Patients taking Colcrys long-term will require frequent blood tests to monitor cell counts along with kidney and liver function.

Common side effects of Colcrys include:

• Nausea or vomiting
• Diarrhea
• Abdominal pain

Contact your doctor if you experience these more serious side effects:

• Black stools
• Blood in urine or stool
• Difficulty breathing
• Headache
• Allergic reaction including swelling on the face, eyelids, mouth, lips or tongue

Why can’t I eat grapefruit while taking Colcrys?

Grapefruit and grapefruit juice contain an enzyme that may increase the amount of Colcrys your body absorbs. This interaction can happen even if you don’t take grapefruit and Colcrys at the same time, and may cause toxic side effects.

What can I do to prevent gout flares?

Dietary management may help prevent gout flares, but it won’t necessarily replace the need for medication. You can try reducing fructose intake, and avoiding foods high in purines including alcohol, herring, mussels, sardines, bacon, turkey, and organ meats.