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IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
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What is CombiPatch?

CombiPatch is a medication patch containing estradiol and norethindrone acetate which is prescribed to treat the symptoms of menopause including hot flashes and vaginal changes such as vaginal dryness, burning and itching. CombiPatch may also be used before menopause to treat a lack of estrogen which may be caused by primary ovarian failure, surgical removal of the ovaries, hypogonadism or other conditions.

Make sure to always read the patient information and instructions before using this medication. Always Follow your doctor’s directions.

  • Peel off the backing of your patch and apply it to a clean, dry area of your lower stomach. Hold down the patch firmly for ten seconds to ensure that it stays on.
  • Do not apply CombiPatch to your breast or to broken, oily or irritated skin, or to areas where it may easily be rubbed off.
  • CombiPatch patches are usually replaced twice a week. When applying a new patch, make sure to apply it to a different area of your skin and wait at least a week before applying a patch to the same area.
  • If your patch falls off, reapply it to a different area. If the patch does not stick completely, apply a new patch for the remaining scheduled period.
  • Do not wear multiple patches at one time.
  • You should never cut a skin patch.
  • Tell your doctor if your condition does not improve.


Tell your doctor and pharmacist:

  • About your drug and other allergies.
  • If you take any other prescription or over-the counter medications.
  • Your medical history particularly of bleeding disorders, heart attack, stroke, blood clots, cancer, heart disease, kidney disease, liver disease liver problems, jaundice, lupus, asthma, epilepsy or other seizure disorders, migraines, porphyria, gallbladder disease, high blood pressure, diabetes, high cholesterol, endometriosis, uterine fibroid tumors, thyroid disorders, high levels of calcium in your blood or hereditary angioedema.
  • If you smoke or are overweight. This may increase your chance of blood clots.
  • If you are breast feeding.

You should also know:

  • CombiPatch should not be used during pregnancy.

CombiPatch Side Effects

Common side effects of CombiPatch include but are not limited to:

  • Irritation or redness where the patch was applied.
  • Breast pain.
  • Vaginal itching, discharge, spotting or breakthrough bleeding.
  • Nausea or vomiting.
  • Stomach cramps
  • Bloating, swelling or weight gain.
  • Headaches.
  • Thinning scalp hair.

Get medical help if you have any of the following side effects of CombiPatch:

  • Heart attack symptoms including nausea, chest pain or pressure, sweating or a pain spreading to your jaw or shoulder.
  • Breast lumps.
  • Swelling or tenderness in the stomach.
  • Symptoms of high levels of calcium in your blood such as nausea, vomiting, muscle weakness, constipation, bone pain, lack of energy or increased thirst or urination.
  • Pelvic pain or unusual vaginal bleeding.
  • Confusion, memory problems or unusual behavior.
  • Signs of increased blood pressure including severe headaches, anxiety, nosebleeds, blurred vision or a pounding in your ears or neck.
  • Blood clot symptoms including a stabbing chest pain, sudden vision loss, shortness of breath, coughing up blood or a pain or warmth in one or both legs.
  • Stroke symptoms including slurred speech, sudden severe headache, vision problems, balance problems or a sudden numbness or weakness especially on one side of the body.
  • Jaundice.
  • Symptoms of an allergic reaction such as difficulty breathing, hives or a swelling in your face, lips or throat.


What should I do if I forget to change my CombiPatch?

Apply the next patch as soon as possible and follow your regular schedule for changing the patch.

What else is CombiPatch called?

CombiPatch is also known as Estalis Patch internationally. Estalis Patch is the same brand name medication with a different name internationally and is not a generic alternative medication.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.

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