Comtan is a prescription medication that is used to treat along with other medications to treat the ‘wearing off’ symptoms of Parkinson’s disease including poor muscle control, muscle spasms, stiffness and tremors. Comtan contains entacapone and works with other medications to increase the level of levodopa in the body.

Make sure to always read the patient information and instructions before using this medication. Always follow your doctor’s directions.

• Comtan must be taken with the medications carbidopa and levodopa.
• This medication can be taken with or without food. Taking Comtan with food may help to prevent nausea.
• Do not stop taking this medication suddenly.
• Drink plenty of liquids while taking this medication.

Tell your doctor and pharmacist:

• About your drug and other allergies.
• If you take any other prescription or over-the-counter medications.
• Your medical history particularly of liver disease, low blood pressure, psychosis, or mental illness.
• If you are pregnant or planning pregnancy.
• If you are breast-feeding.

You should also know:

• Comtan may cause you to fall asleep during normal activities. Take care when driving or operating machinery.
• This medication may cause dehydration. Drink plenty of liquids while taking Comtan.
• Do not drink alcohol while taking Comtan as this can increase the side effects of this medication.
• This medication may cause intense urges including urges to gamble or sexual urges. Speak to your doctor if this occurs.
• People with Parkinson’s disease may be more likely to develop skin cancer. Speak to your doctor for more information.

Common side effects of Comtan include but are not limited to:

• Nausea or vomiting.
• Stomach pain or diarrhea.
• Uncontrolled muscle movements.
• Dry mouth.
• Feeling dizzy or drowsy.
• Changes to the color of urine.

Get medical help if you have any of the following side effects of entacapone:

• Unusual thoughts or behavior.
• Agitation, confusion, or hallucinations.
• Fast or uneven heartbeats.
• Severe or persistent diarrhea.
• Feeling like you might pass out.
• High fever or sweating.
• Tremors.
• Rigid muscles.
• Unexplained muscle pain, tenderness or weakness with fever, dark urine, and unusual tiredness.
• Symptoms of an allergic reaction such as difficulty breathing, hives, or swelling in your face, lips, or throat.

What should I do if I miss a dose of Comtan?

If you miss a dose of Comtan, you should take it as soon as you remember. However, if it is almost time for your next dose, then skip your missed dose.

What is the strength of Comtan?

Comtan is available in a strength of 200mg.