Contact your doctor immediately if there are signs of liver or pancreas problems, including appetite loss, upper stomach pain, nausea or vomiting, dark urine, face swelling, and jaundice.
Get emergency medical help if you suspect an allergic reaction, severe skin reaction, or other serious side effects such as:
signs of a liver or pancreas issue (see above), confusion, fatigue, coldness, vomiting, change in mental state, easy bruising, unusual bleeding, purple or red pinpoint spots beneath skin, severe drowsiness, worsening seizures, or signs of inflammation.
Inform your doctor of mood or behavior changes, anxiety, panic attacks, sleeping difficulties, impulsivity, aggression, or thoughts of suicide or self-harm.
Other side effects of Depakote include:
nausea and vomiting, mild stomach pain, diarrhea, headache, mild dizziness, weakness, tremors, balancing and walking issues, blurred or double vision, changes in appetite, and weight gain.
Depakote may increase sensitivity to sunburn. Use a sunscreen (SPF 30 or higher) and avoid tanning beds.
Note that side effects listed here are not exhaustive.