1. Strength


2. Quantity

Prescription Required
IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
Difference between Brand & Generic?

What is Depen?

Depen is a prescription medication that is used to treat a number of conditions including Wilson’s disease, rheumatoid arthritis and to reduce urine levels in people with cystinuria. Depen contains penicillamine and works by removing excess copper in the blood stream.

Make sure to always read the patient information and instructions before using this medication. Always follow your doctor’s directions.

  • Depen should be taken on an empty stomach. Take this medication either one hour before or two hours after a meal.
  • Drink plenty of fluids while taking this medication. Do not drink milk within an hour of taking Depen.
  • Your condition may worsen when you first start taking this medication.
  • Depen may be prescribed as part of a treatment plan that may also include a special diet.


Tell your doctor and pharmacist:

  • About your drug and other allergies.
  • If you take any other prescription or over-the-counter medications, especially gold injections, malaria medications or cancer medication.
  • Your medical history particularly of kidney disease, damaged blood cells, liver disease, stomach ulcers or a weak immune system.
  • If you are malnourished.
  • If you are pregnant. You may not be able to take this medication.

You should also know:

  • This medication may be taken with a diet plan. Follow your doctor’s directions carefully.
  • Depen should not be used if you are breast-feeding.

Side Effects of Depen

Common side effects of Depen include but are not limited to:

  • Wounds that do not heal.
  • Skin changes including pimples or wrinkling.
  • Decreased sense of taste.
  • Nausea or vomiting.
  • Numbness or tingling.
  • Loss of appetite.
  • Stomach pain.
  • Diarrhea.
  • Ringing in the ears.

Get medical help if you have any of the following side effects of penicillamine.

  • New or worsening joint pain.
  • Fever.
  • Double vision.
  • Breathing problems.
  • New or worsening cough.
  • Urine that is painful, burns, bloody, or foamy.
  • Lower back pain.
  • Breathing problems.
  • Skin rash or peeling.
  • Swelling in the hands, legs, or feet.
  • Watery blisters.
  • Muscle weakness in the face, arms, and legs.
  • Drooping eyelids.
  • Trouble swallowing or chewing.
  • Mouth ulcers or blisters
  • Red or swollen gums.
  • Signs of a low blood cell count such as fever, pale skin, cold hands and feet, skin sores, chills, tiredness, unusual bleeding, easy bruising, shortness of breath or lightheadedness.
  • Symptoms of an allergic reaction such as difficulty breathing, hives or swelling in your face, lips or throat.


What should I do if I miss a dose of Depen?

If you miss a dose of Depen, you should take it as soon as you remember. However, if it is almost time for your next dose, then skip your missed dose.

What else is Depen called?

Depen is also known as D-Penamine internationally. D-Penamine is the same brand name medication with a different name internationally and is not a generic alternative medication. Generic Depen is called penicillamine.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

Your Lowest Price, Guaranteed

Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-385-5040 and a member of our CareTeam will be happy to assist you.

Call 1-877-385-5040
* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.

Real Customers, Honest Reviews

I have had good experiences with RX Connected. Rich
Richard February 28, 2020

Real Customers, Honest Reviews

I placed my first order last November. The process is exactly as I was told. I emailed my information, and sent original copies to them. Every time I have refilled my medication the representative has been friendly,and knowledgeable. I called today inquiring about the current status of a refill. After a short time, the representative gave me the information I needed (so I wouldn't worry). I appreciate the savings, and the professionalism shown by all the employees I've had contact with via phone. Keep up the good work.
Alex February 27, 2020

Real Customers, Honest Reviews

Like most other people, my prescription was very expensive and not covered. I started looking and found this pharmacy. While it takes approximately a month to receive your script, it's worth it for the savings.
Margaret February 26, 2020

Real Customers, Honest Reviews

In the past, I had heard people talk about getting some of their prescriptions from Canada due to the high prices in the US. I never really considered it until after a local doctor suggested RX Connected for one of my recommended medications. The price for the medication here was very expensive and not covered by by Medicare drug supplement plan. I'm very grateful that he told me about RX Connected. I have since told several other people about RX Connected. After your doctor writes the initial prescription, you just send it in, and the process begins. They are careful, professional, and send me my medication by mail, on time, like clock-work. Thank you RX Connected!
Judy February 25, 2020

Real Customers, Honest Reviews

Always very polite and helpful. I appreciate so much the reminders when it's time to renew my prescription! Thank you!
Betty February 21, 2020

Real Customers, Honest Reviews

great thanks
Helen February 21, 2020

Real Customers, Honest Reviews

Sheffield February 21, 2020

Real Customers, Honest Reviews

Great service.
Joe February 21, 2020

Real Customers, Honest Reviews

Patricia February 21, 2020

Real Customers, Honest Reviews

Easy process and reasonable pricing . Both good reasons to use this company .
Terry October 25, 2019
Read All Reviews
Write a Review