RxConnected Prescription Required
IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
Available 7 Days a Week


Express shipping

May be available upon request

Lowest Price, Guaranteed

match price or beat it by 10% *

Life-Time Free shipping

Find out if you're eligible!

  • Delivery time is between 8-14 business days.
  • Express shipping may be available upon request

Buy Effexor XR (Venlafaxine Hyrdrochloride XR) Online

Do you want to save up to 90% on the cost of Effexor XR and other prescription medications? Then buy your drugs online with RXConnected. We are a safe, certified online pharmacy giving customers in the US the opportunity to buy their medication at affordable prices.

What is Effexor XR?

Effexor XR (venlafaxine) is an anti-depressant medication which is used to treat major depressive disorder, panic disorder and anxiety by affecting chemicals in the brain which may be unbalanced. Taking venlafaxine can improve your mood and energy levels and restore your interest in daily living.

Make sure to always read the patient information and instructions before using this medication. Always follow your doctor’s directions.

  • Take Effexor XR with food at the same time each day.
  • Swallow capsules whole without chewing.
  • If you struggle to swallow Effexor XR capsules whole, you may open the capsule and sprinkle the medication onto applesauce and swallow the mixture without chewing.
  • It may take several weeks for your symptoms to improve. Continue taking this mediation as directed.


Tell your doctor and pharmacist:

  • About your drug and other allergies.
  • If you take any other prescription or over-the-counter medications.
  • Your medical history particularly of bleeding problems, heart disease, bleeding or blood clotting disorders, kidney disease, bipolar disorder, diabetes, thyroid disorder, seizures, liver disease, cirrhosis, glaucoma, or low levels of sodium in your blood.
  • If you are pregnant, planning pregnancy or breast-feeding.

You should also know:

  • Effexor XR may cause you to have a false positive drug screening test. Tell the laboratory staff that you are taking venlafaxine.
  • Do not use Effexor within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
  • Young people may have suicidal thoughts when first taking an antidepressant. Your family or caregivers should be alert to changes in your symptoms and mood.
  • Effexor XR is not approved to be used by anyone younger than 18.

Side Effects of Effexor XR

Common side effects of Effexor XR include but are not limited to:

  • Drowsiness, yawning or trouble sleeping.
  • Nausea or constipation.
  • Nervousness.
  • Dizziness.
  • Unusual sweating.
  • Dry mouth.
  • Loss of appetite.
  • Blurred vision.

Get medical help if you have any of the following side effects of Effexor XR:

  • An increase in your blood pressure.
  • Decreased interest in sex or changes in your sexual ability.
  • Coughing which doesn’t go away.
  • Chest pain.
  • Easy bruising or bleeding.
  • Black or bloody stools or vomit which looks like coffee ground.
  • Widened pupils, eye pain, swelling or redness or vision changes such as rainbows around lights at night.
  • Seizures or shaking.
  • Muscle cramps or weakness.
  • Shortness of breath.
  • Severe or pounding headache.
  • Serotonin syndrome symptoms including fast heartbeat, hallucinations, severe dizziness, twitching muscles, loss of coordination, unexplained fever, unusual agitation or restlessness or severe nausea, severe vomiting or severe diarrhea.
  • Symptoms of an allergic reaction such as difficulty breathing, hives or swelling in your face, lips or throat.


What should I do if I miss a dose of Effexor XR?

If you miss a dose of Effexor XR, you should take it as soon as you remember. However, if it is almost time for your next dose, then skip your missed dose.

What is the strength of Effexor XR?

Both Effexor XR and the generic alternative venlafaxine hydrochloride XR are available in 37.5mg, 75mg and 150mg strengths.

Hear From People Like You

Don't just take our word, listen to real customers whose lives have changed for the better.

Real People, Trustworthy Reviews

See what others are saying about their experience!

Bernice R

March 23, 2023

I am very pleased with RX Connected. My conversations with everyone there has been positive and I really appreciate your quick response if I have a question.

MaryJean P

October 26, 2022

I really appreciate the reminders when I am due for refills. The staff are efficient and courteous.

Nancy S

October 7, 2022

Your service has been amazing!


October 1, 2022

Considering conditions in parts of the world today delivery was as usual. Meds arrived in the normal amount of time despite traveling distance.


September 14, 2022

The experiences I have had with Rx Connected have always been very positive. The representatives are always polite and clear with the instructions. I especially appreciate the calls I get explaining any delay or change in delivery. Thank you so much.

Joyce W

September 7, 2022

I’m always happy with your service.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

Your Lowest Price, Guaranteed

Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-385-5040 and a member of our CareTeam will be happy to assist you.

Call 1-877-385-5040
* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.