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What is Estrace?

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Estrace is a female hormone medication containing estradiol. Estrace is used to reduce the symptoms of menopause including hot flashes and vaginal dryness. Estradiol may also be prescribed to prevent osteoporosis in menopausal women and to replace estrogen in women with conditions that cause a lack of natural estrogen in women. Estrace may also be used as part of cancer treatment for both men and women.

Make sure to always read the patient information and instructions before using this medication. Always follow your doctor’s directions.

  • Take Estrace orally with or without food. Taking Estrace with food or right after a meal may help to prevent stomach upset.
  • Your doctor may want to check your progress regularly while taking this medication.
  • Self-examine your breasts for lumps each month and have annual mammograms while taking Estrace.
  • Estrace is most effective when it is taken regularly. Try to take it at the same time each day.


Tell your doctor and pharmacist:

  • About your drug and other allergies.
  • If you take any other prescription or over-the-counter medications.
  • Your medical history particularly of unusual vaginal bleeding, liver disease, heart attack, stroke, blood clots, heart problems, hereditary blood disorders, cancer, liver problems, jaundice, kidney disease, gallbladder disease, asthma, epilepsy, seizures, migraines, lupus, endometriosis, uterine fibroid tumours, hereditary angioedema, porphyria, thyroid disorders or high levels of calcium in your blood.
  • If you are breastfeeding.
  • If you will be having or have recently had surgery or if you will be confined to a bed or chair for a period of time. These conditions may increase the chance of blood clots.

You should also know:

  • Estrace should not be used during pregnancy.
  • You should not smoke while taking this medication. Estrogens combined with smoking can increase the risk of stroke, heart attack, blood clots and high blood pressure particularly in women over 35.

Estrace Side Effects

Common side effects of Estrace include but are not limited to:

  • Vaginal itching or discharge.
  • Changes to your menstrual periods.
  • Breakthrough bleeding.
  • Headache, back pain or breast pain.
  • Nausea, stomach cramps, vomiting or diarrhea.
  • Sleep problems.
  • Mood changes.
  • Weight gain.
  • Cold symptoms including sore throat, sinus pain or stuffy nose.

Get medical help if you have any of the following side effects of Estrace:

  • Stomach tenderness or swelling.
  • Unusual behavior, confusion or memory problems.
  • Jaundice.
  • Breast lumps.
  • Unusual vaginal bleeding or pelvic pain.
  • Signs of high levels of calcium in your blood including lack of energy, bone pain, muscle weakness, constipation, nausea, vomiting or increased thirst or urination.
  • Stroke symptoms including sudden severe headache, slurred speech, vision problems, balance problems or a sudden numbness or weakness especially to one side of the body.
  • Blood clot symptoms particularly stabbing chest pain, shortness of breath, sudden vision loss, coughing up blood or warmth in one or both legs.
  • Heart attack symptoms such as nausea, sweating, chest pain, chest pressure or a pain which spreads to your jaw or shoulder.
  • Symptoms of an allergic reaction such as difficulty breathing, hives or swelling in your face, lips or throat.


What should I do if I miss a dose of Estrace?

If you miss a dose of Estrace, you should take it as soon as you remember. However, if it is almost time for your next dose, then skip your missed dose.

What is the generic alternative to Estrace?

Generic Estrace is known as estradiol and is available in the same 0.5mg, 1mg and 2mg strengths.

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A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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