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What is Januvia?

Januvia (sitagliptin) is a prescription drug that helps to control blood sugar levels in patients with Type 2 diabetes. It belongs to a class of drugs called DPP-4 inhibitors that influence alpha and beta cells in the pancreas to help regulate glucose levels by regulating and increasing the release of insulin especially after eating. Sitagliptin also sends signals to the liver to stop producing glucose when there is too much sugar in the blood. Januvia should be taken as part of a lifestyle program that includes changes in diet, exercise, and weight loss if necessary.

Always follow your doctor’s instructions when taking Januvia.

  • Januvia is taken once daily, with or without food.
  • Try to take Januvia at the same time each day.
  • Your doctor may adjust dosage to better control your diabetes, but it is important that you don’t change dosage on your own.
  • Continue taking Januvia even when you feel well. Do not stop taking this medication unless directed to by a doctor.


Before taking Januvia, inform your doctor if you:

  • Kidney disease (including dialysis)
  • Diabetic ketoacidosis
  • Pancreatitis

Tell your doctor if you are pregnant or breastfeeding

Alcohol should be limited as this can increase your risk of low blood sugar levels.

Regular blood sugar monitoring is an important part of diabetes treatment. Low blood sugar can occur after skipping meals, strenuous exercise, or drinking alcohol. Learn to recognize signs of low blood sugar, including headache, sweating, weakness, confusion, and tremor. Carry sources of sugar such as glucose tablets or hard candy that can be used in case of low blood sugar.

Januvia is not meant to treat Type 1 diabetes or diabetic ketoacidosis.

Side Effects of Januvia

Some of the most common side effects of Januvia include:

  • Upset stomach, diarrhea.
  • Upper respiratory infection.
  • Headaches or joint pains.
  • Increased urination.

More serious side effects include:

  • Signs of pancreatitis: severe pain in stomach, nausea and vomiting, loss of appetite.
  • Urinating less than usual or not at all.
  • Shortness of breath.
  • Skin reaction: swelling in face, burning in eyes, red or purple rash.


Can I take Januvia if I have Type 1 diabetes?

No. Januvia is specifically for patients with Type 2 diabetes, and should only be taken under the care of a doctor.

How long will I need to take Januvia?

Continue taking Januvia as directed by your doctor. Lifestyle changes including diet and exercise can help better control your diabetes, and may reduce the need to take Januvia.

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