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Pentasa contains mesalamine and is used to treat ulcerative colitis and Crohn disease and to relieve their symptoms including diarrhea, rectal bleeding and stomach pain. Mesalamine works by affecting substances in your body and decreasing swelling in your colon.

Make sure to always read the patient information and instructions before using this medication. Always follow your doctor’s directions.

• Pentasa can be taken with or without food.
• Swallow Pentasa whole without crushing, chewing or breaking a capsule.
• If you cannot swallow Pentasa whole, the capsule may be opened and the contents sprinkled onto applesauce or yogurt and then consumed immediately.
• Tell your doctor if your symptoms do not improve.

Tell your doctor and pharmacist:

• About your drug and other allergies.
• If you take any other prescription or over-the-counter medications.
• Your medical history particularly of stomach conditions such as pyloric stenosis, heart disease, liver disease, kidney disease, stomach blockage or intestinal blockage.
• If you are pregnant or planning on pregnancy.
• If you are breast-feeding. Mesalamine can pass into breast milk an may harm a nursing infant.

You should also know:

• Pentasa may cause unusual test results for certain medical tests. Tell all of your doctors that you take this medication.

Common side effects of Pentasa include but are not limited to:

• Nausea, stomach pain or diarrhea.
• Constipation.
• Headache or back pain.
• Flu-like symptoms including sore throat, sinus pain, runny or stuffy nose.
• Rash.
• Abnormal liver function tests.

Get medical help if you have any of the following side effects of Pentasa:

• Severe stomach pain or cramping.
• Bloody diarrhea, bloody or tarry stools.
• Fever, headache or skin rash.
• Coughing up blood.
• Vomit which looks like coffee grounds.
• Symptoms of kidney problems such as tiredness, shortness of breath, swelling in your feet or ankles, or painful, difficult, little or no urination.
• Symptoms of liver problems including loss of appetite, pain in your upper stomach, tiredness, easy bruising or bleeding, dark urine, clay-colored stools or jaundice.
• Symptoms of an allergic reaction such as difficulty breathing, hives or swelling in your face, lips or throat.

What should I do if I miss a dose of Pentasa?

If you miss a dose of Pentasa, you should take it as soon as you remember. However, if it is almost time for your next dose, then skip your missed dose.

Is there a generic alternative for Pentasa?

Unfortunately at the moment, there is no therapeutically equivalent generic alternative for Pentasa.