Prempro is a prescription medication used to treat symptoms of menopause (including hot flashes and vaginal changes) and to prevent osteoporosis in menopausal women. Prempro is made from a combination of the female hormones estrogen and progesterone. Estrogen is required for many processes in the body, while progesterone regulates ovulation and menstruation.

Always follow your doctor’s instructions and use Prempro exactly as prescribed.

• Take Prempro with a full glass of water. If you have a sensitive stomach, take Prempro with food to avoid irritation.

Prempro can increase your risk of blood clots, stroke or heart attack. This is especially true if you are overweight, have diabetes, high blood pressure, high cholesterol, or smoke.

Pregnant or breastfeeding women should not use Prempro.

Long-term use of Prempro can increase the risk of breast, uterine, or ovarian cancer.

Before taking Prempro, inform your doctor if you have any of the following:

• Heart, liver, kidney or gallbladder disease
• Hysterectomy
• Asthma
• Seizures
• Thyroid issues
• Migraines
• Lupus
• Endometriosis
• High calcium levels

Common side effects of Prempro include:

• Headache
• Depression
• Nausea
• Breast pain

Inform your doctor immediately if you experience:

• Signs of stroke – numbness or weakness on one side of the body, slurred speech, vision problems, sudden headache
• Heart attack symptoms – pain or pressure in the chest, arm or jaw pain, sweating, nausea
• Jaundice
• Swelling or pain in stomach
• Unusual vaginal bleeding
• A lump in your breast
• Memory problems or unusual behavior

What time of day should I use Prempro?

You can take Prempro at any time of day that’s convenient for you. Try to take Prempro at the same time every day.

Will my menopause symptoms go away on their own?

Some menopause symptoms, including hot flashes, are likely to go away on their own. But other symptoms like vaginal dryness may persist due to lack of estrogen. Talk to your doctor about your symptoms and how long you should take Prempro for.

Can I buy Prempro over the counter?

No. Prempro is only available with a prescription at this time.