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Prescription Required
IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
Difference between Brand & Generic?

What is Prempro?

Buying Prempro from a certified Canadian pharmacy has never been easier. Buying medication from RXConnected is quick, efficient and affordable. Order online or call us today and we will ship your prescription and over the counter medications directly to your door saving you long lines and unnecessary hassle.

Prempro is a prescription medication used to treat symptoms of menopause (including hot flashes and vaginal changes) and to prevent osteoporosis in menopausal women. Prempro is made from a combination of the female hormones estrogen and progesterone. Estrogen is required for many processes in the body, while progesterone regulates ovulation and menstruation.

Make sure to always read the patient information and instructions before using this medication. Always follow your doctor’s directions.

  • Take Prempro with a full glass of water.
  • If you have a sensitive stomach, take Prempro with food to avoid irritation.
  • Take Prempro at the same time each day.
  • Self-examine your breasts for lumps on a monthly basis, have regular mammograms and see your doctor on a regular basis while taking Prempro.


Prempro can increase your risk of blood clots, stroke or heart attack. This is especially true if you are overweight, have diabetes, high blood pressure, high cholesterol, or smoke.

Pregnant or breastfeeding women should not use Prempro.

Long-term use of Prempro can increase the risk of breast, uterine, or ovarian cancer.

Before taking Prempro, inform your doctor if you have any of the following:

  • Heart, liver, kidney or gallbladder disease
  • Hysterectomy
  • Asthma
  • Seizures
  • Thyroid issues
  • Migraines
  • Lupus
  • Endometriosis
  • High calcium levels

Side Effects

Common side effects of Prempro include:

  • Headache
  • Depression
  • Nausea
  • Breast pain

Inform your doctor immediately if you experience:

  • Signs of stroke – numbness or weakness on one side of the body, slurred speech, vision problems, sudden headache
  • Heart attack symptoms – pain or pressure in the chest, arm or jaw pain, sweating, nausea
  • Jaundice
  • Swelling or pain in stomach
  • Unusual vaginal bleeding
  • A lump in your breast
  • Memory problems or unusual behavior


What time of day should I use Prempro?

You can take Prempro at any time of day that’s convenient for you. Try to take Prempro at the same time every day.

Will my menopause symptoms go away on their own?

Some menopause symptoms, including hot flashes, are likely to go away on their own. But other symptoms like vaginal dryness may persist due to lack of estrogen. Talk to your doctor about your symptoms and how long you should take Prempro for.

Can I buy Prempro over the counter?

No. Prempro is only available with a prescription at this time.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

Your Lowest Price, Guaranteed

Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-385-5040 and a member of our CareTeam will be happy to assist you.

Call 1-877-385-5040
* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.

Real Customers, Honest Reviews

I have had good experiences with RX Connected. Rich
Richard February 28, 2020

Real Customers, Honest Reviews

I placed my first order last November. The process is exactly as I was told. I emailed my information, and sent original copies to them. Every time I have refilled my medication the representative has been friendly,and knowledgeable. I called today inquiring about the current status of a refill. After a short time, the representative gave me the information I needed (so I wouldn't worry). I appreciate the savings, and the professionalism shown by all the employees I've had contact with via phone. Keep up the good work.
Alex February 27, 2020

Real Customers, Honest Reviews

Like most other people, my prescription was very expensive and not covered. I started looking and found this pharmacy. While it takes approximately a month to receive your script, it's worth it for the savings.
Margaret February 26, 2020

Real Customers, Honest Reviews

In the past, I had heard people talk about getting some of their prescriptions from Canada due to the high prices in the US. I never really considered it until after a local doctor suggested RX Connected for one of my recommended medications. The price for the medication here was very expensive and not covered by by Medicare drug supplement plan. I'm very grateful that he told me about RX Connected. I have since told several other people about RX Connected. After your doctor writes the initial prescription, you just send it in, and the process begins. They are careful, professional, and send me my medication by mail, on time, like clock-work. Thank you RX Connected!
Judy February 25, 2020

Real Customers, Honest Reviews

Always very polite and helpful. I appreciate so much the reminders when it's time to renew my prescription! Thank you!
Betty February 21, 2020

Real Customers, Honest Reviews

great thanks
Helen February 21, 2020

Real Customers, Honest Reviews

Sheffield February 21, 2020

Real Customers, Honest Reviews

Great service.
Joe February 21, 2020

Real Customers, Honest Reviews

Patricia February 21, 2020

Real Customers, Honest Reviews

Easy process and reasonable pricing . Both good reasons to use this company .
Terry October 25, 2019
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