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  • Delivery time is between 8-14 business days.
  • Express shipping may be available upon request

What is Prempro?

Buying Prempro from a certified Canadian pharmacy has never been easier. Buying medication from RXConnected is quick, efficient and affordable. Order online or call us today and we will ship your prescription and over the counter medications directly to your door saving you long lines and unnecessary hassle.

Prempro is a prescription medication used to treat symptoms of menopause (including hot flashes and vaginal changes) and to prevent osteoporosis in menopausal women. Prempro is made from a combination of the female hormones estrogen and progesterone. Estrogen is required for many processes in the body, while progesterone regulates ovulation and menstruation.

Make sure to always read the patient information and instructions before using this medication. Always follow your doctor’s directions.

  • Take Prempro with a full glass of water.
  • If you have a sensitive stomach, take Prempro with food to avoid irritation.
  • Take Prempro at the same time each day.
  • Self-examine your breasts for lumps on a monthly basis, have regular mammograms and see your doctor on a regular basis while taking Prempro.


Prempro can increase your risk of blood clots, stroke or heart attack. This is especially true if you are overweight, have diabetes, high blood pressure, high cholesterol, or smoke.

Pregnant or breastfeeding women should not use Prempro.

Long-term use of Prempro can increase the risk of breast, uterine, or ovarian cancer.

Before taking Prempro, inform your doctor if you have any of the following:

  • Heart, liver, kidney or gallbladder disease
  • Hysterectomy
  • Asthma
  • Seizures
  • Thyroid issues
  • Migraines
  • Lupus
  • Endometriosis
  • High calcium levels

Side Effects

Common side effects of Prempro include:

  • Headache
  • Depression
  • Nausea
  • Breast pain

Inform your doctor immediately if you experience:

  • Signs of stroke – numbness or weakness on one side of the body, slurred speech, vision problems, sudden headache
  • Heart attack symptoms – pain or pressure in the chest, arm or jaw pain, sweating, nausea
  • Jaundice
  • Swelling or pain in stomach
  • Unusual vaginal bleeding
  • A lump in your breast
  • Memory problems or unusual behavior


What time of day should I use Prempro?

You can take Prempro at any time of day that’s convenient for you. Try to take Prempro at the same time every day.

Will my menopause symptoms go away on their own?

Some menopause symptoms, including hot flashes, are likely to go away on their own. But other symptoms like vaginal dryness may persist due to lack of estrogen. Talk to your doctor about your symptoms and how long you should take Prempro for.

Can I buy Prempro over the counter?

No. Prempro is only available with a prescription at this time.

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Bernice R

March 23, 2023

I am very pleased with RX Connected. My conversations with everyone there has been positive and I really appreciate your quick response if I have a question.

MaryJean P

October 26, 2022

I really appreciate the reminders when I am due for refills. The staff are efficient and courteous.

Nancy S

October 7, 2022

Your service has been amazing!


October 1, 2022

Considering conditions in parts of the world today delivery was as usual. Meds arrived in the normal amount of time despite traveling distance.


September 14, 2022

The experiences I have had with Rx Connected have always been very positive. The representatives are always polite and clear with the instructions. I especially appreciate the calls I get explaining any delay or change in delivery. Thank you so much.

Joyce W

September 7, 2022

I’m always happy with your service.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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