Canadian Pharmacy > Pristiq ER (Desvenlafaxine)
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Buy Pristiq (Desvenlafaxine)

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Desvenlafaxine ER (Generic)
QTY Price Unit Price Select
100 $187.00 $1.87 BUY
Pristiq ER (Desvenlafaxine)
QTY Price Unit Price Select
84 $249.00 $2.96 BUY
168 $449.00 $2.67 BUY
252 $661.00 $2.62 BUY
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Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-385-5040 and a member of our CareTeam will be happy to assist you.

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Pristiq is a prescription antidepressant used to treat major depressive disorder. It belongs to a class of drug called SNRIs (selective serotonin and norepinephrine reuptake inhibitors), and works by affecting chemicals in the brain.


Always follow your doctor’s instructions and use Pristiq exactly as prescribed.

  • Take Pristiq once daily with water, with or without food.
  • Swallow tablet whole. Do not crush, chew or break.
  • Your symptoms may not improve for several weeks. Do not discontinue Pristiq unless directed by your doctor.

Some Pristiq tablets are made with a shell that isn’t absorbed by the body. You may see part of the tablet in your stool.


Do not take Pristiq less than 7 days before or 14 days after an MAOI drug.

Young people may have suicidal thoughts when they begin taking an antidepressant like Pristiq. Patients should be carefully monitored until they’ve adjusted to the drug.

NSAIDs and blood thinners can increase your risk of bleeding while on Pristiq. Check with your doctor before using these medications.

Before taking Pristiq, inform your doctor if you have any of the following:

  • Liver or kidney disease
  • Heart disease, stroke, high cholesterol, high blood pressure
  • Glaucoma
  • Bipolar disorder
  • Suicidal thoughts
  • Seizures
  • Bleeding or clotting disorder
  • Low sodium levels

Some drugs may interact with Pristiq to cause serotonin syndrome. Inform your doctor if you take any of the following:

  • Opioids
  • Stimulants
  • Herbal supplements or products
  • Parkinson’s medication
  • Other drugs for depression or mental illness
  • Migraine medication
  • Drugs to prevent nausea or vomiting
  • Antibiotics
Side Effects

Common side effects of Pristiq ER include:

  • Sexual side effects, including erectile dysfunction and decreased sex drive
  • Insomnia or drowsiness
  • Nausea, constipation, decreased appetite
  • Dizziness, anxiety
  • Sweating

Contact your doctor if you experience these more serious side effects:

  • Serotonin syndrome – hallucinations, confusion, restlessness, muscle stiffness, vomiting, diarrhea, fever, fast heart rate, loss of coordination
  • Seizures
  • Chest pain, coughing, trouble breathing
  • Low sodium levels – headache, weakness, confusion, hallucinations, memory problems
  • Bruising or bleeding, coughing up blood, blood in urine or stool

Can I take ibuprofen or aspirin while taking Pristiq?

NSAIDs like ibuprofen and aspirin can increase your risk of bleeding while on Pristiq. Ask your doctor which pain relief drug is safe for you to take.

Is it safe to stop taking Pristiq?

Like other antidepressant drugs, quitting Pristiq abruptly can result in withdrawal symptoms. Talk to your doctor about tapering off of Pristiq, and never stop taking it without your doctor’s guidance.

IMPORTANT NOTE: The information provided on the website is intended to facilitate awareness about healthcare products and medical conditions generally but it is not a substitute for professional medical attention or advice. You should always speak with a qualified healthcare practitioner before taking any prescription or non-prescription drug.
IMPORTANT NOTE: Please note that not all medications, including any referenced on this page, are dispensed from our affiliated Canadian pharmacy. The medications in your order may be filled and shipped from an approved International fulfillment center located in a country other than Canada. In addition to dispensing medications from our Canadian pharmacy, medication orders are also filled and shipped from international fulfillment centers that are approved by the regulatory bodies from their respective countries. Medication orders are filled and shipped from approved fulfillment centers around the world including, but not limited to, Canada, Singapore, United Kingdom, New Zealand, Turkey, Mauritius, India, Australia, and the United States. The items in your order may be filled and shipped from any one of the above jurisdictions. The products are sourced from various countries including, but not limited to, Canada, United Kingdom, New Zealand, Turkey, India, Australia, and the United States. All of our affiliated fulfillment centers have been approved by the regulatory bodies from their respective countries.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

What's the difference between generic drugs and brand name drugs?

What's the difference between the branded products you sell and the ones I get locally?
The branded drugs we sell are chemically and therapeutically no different from the ones you get in your local pharmacy. They both generally come from the same exact manufacturer. Generally, the main difference* is in the packaging and the price. Our packaging may be different from what you get locally, but we're also much cheaper.

* Other differences may include differences in trade name, form, and general appearance.

Why are there packaging differences?
Due to differences in government regulation, different countries have different packaging requirements. For example, a product in Canada (or any other country) will have different packaging than the same product in the US even though both drugs are chemically and therapeutically equivalent and are generally manufactured by the same exact company.

Why are your drugs so much cheaper?
Due to government price controls, medications from Canada and many other countries are often significantly cheaper than in the United States. Also, other countries may have more affordable generic versions of drugs, which may not yet be available in the US.

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