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What is Pristiq ER?

Pristiq ER (desvenlafaxine) is a prescription antidepressant used to treat major depressive disorder. It belongs to a class of drug called SNRIs (selective serotonin and norepinephrine reuptake inhibitors), and works by affecting chemicals in the brain.

Always follow your doctor’s instructions and use Pristiq exactly as prescribed.

• Take Pristiq once daily with water, with or without food.
• Swallow tablet whole. Do not crush, chew or break.
• Your symptoms may not improve for several weeks. Do not discontinue Pristiq unless directed by your doctor.

Some Pristiq tablets are made with a shell that isn’t absorbed by the body. You may see part of the tablet in your stool.

Do not take Pristiq less than 7 days before or 14 days after an MAOI drug.

Young people may have suicidal thoughts when they begin taking an antidepressant like Pristiq. Patients should be carefully monitored until they’ve adjusted to the drug.

NSAIDs and blood thinners can increase your risk of bleeding while on Pristiq. Check with your doctor before using these medications.

Before taking Pristiq, inform your doctor if you have any of the following:

• Liver or kidney disease
• Heart disease, stroke, high cholesterol, high blood pressure
• Glaucoma
• Bipolar disorder
• Suicidal thoughts
• Seizures
• Bleeding or clotting disorder
• Low sodium levels

Some drugs may interact with Pristiq to cause serotonin syndrome. Inform your doctor if you take any of the following:

• Opioids
• Stimulants
• Herbal supplements or products
• Parkinson’s medication
• Other drugs for depression or mental illness
• Migraine medication
• Drugs to prevent nausea or vomiting
• Antibiotics

Common side effects of Pristiq ER include:

• Sexual side effects, including erectile dysfunction and decreased sex drive
• Insomnia or drowsiness
• Nausea, constipation, decreased appetite
• Dizziness, anxiety
• Sweating

Contact your doctor if you experience these more serious side effects:

• Serotonin syndrome – hallucinations, confusion, restlessness, muscle stiffness, vomiting, diarrhea, fever, fast heart rate, loss of coordination
• Seizures
• Chest pain, coughing, trouble breathing
• Low sodium levels – headache, weakness, confusion, hallucinations, memory problems
• Bruising or bleeding, coughing up blood, blood in urine or stool

Can I take ibuprofen or aspirin while taking Pristiq?

NSAIDs like ibuprofen and aspirin can increase your risk of bleeding while on Pristiq. Ask your doctor which pain relief drug is safe for you to take.

Is it safe to stop taking Pristiq?

Like other antidepressant drugs, quitting Pristiq abruptly can result in withdrawal symptoms. Talk to your doctor about tapering off of Pristiq, and never stop taking it without your doctor’s guidance.