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What is Soriatane?

Soriatane (acitretin) is used to treat severe psoriasis (abnormal growth of skin cells that causes red, thickened, or scaly skin). Acitretin is in a class of medications called retinoids. The way acitretin works is not known. Soriatane is not a cure for psoriasis and you may relapse once you stop taking this medication. 


Soriatane or generic Soriatane comes as a capsule to take by mouth. It is usually taken once a day with the main meal.

Take acitretin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Take acitretin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Your doctor may start you on a low dose of acitretin and gradually increase your dose.

Acitretin controls psoriasis but does not cure it. It may take 2–3 months or longer before you feel the full benefit of acitretin. Your psoriasis may get worse during the first few months of treatment. This does not mean that acitretin will not work for you, but tell your doctor if this happens. C

ontinue to take acitretin even if you feel well. Do not stop taking acitretin without talking to your doctor. After you stop taking acitretin, your symptoms may come back. Tell your doctor if this happens. Do not use leftover acitretin to treat a new flare-up of psoriasis. A different medication or dose may be needed.


Before taking acitretin, tell your doctor and pharmacist if you have had a serious allergic reaction (difficulty breathing or swallowing, hives, itching, or swelling of the face, throat, tongue, lips, or eyes) to acitretin, other retinoids such as adapalene (Differen, in Epiduo), alitretinoin (Panretin), isotretinoin (Absorica, Accutane, Amnesteem, Claravis, Myorisan, Sotret, Zenatane), tazarotene (Avage, Fabior, Tazorac), tretinoin (Atralin, Avita, Renova, Retin-A), or any of the ingredients in acitretin capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

Tell your doctor if you are taking any of the following medications: methotrexate (Trexall) or tetracycline antibiotics such as demeclocycline, doxycycline (Doryx, Monodox, Oracea, Periostat, Vibramycin), minocycline (Dynacin, Minocin, Solodyn), and tetracycline (Sumycin, in Helidac, in Pylera) while taking acitretin. Your doctor will probably tell you not to take acitretin if you are taking one or more of these medications.

Also tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. 

Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Tell your doctor if you have or have ever had the following conditions: if you have high cholesterol or triglyceride levels, a family history of high cholesterol levels, or kidney disease. Your doctor may tell you that you should not take acitretin.

Tell your doctor if you drink large amounts of alcohol; if you have diabetes or high blood sugar, spinal problems, depression, or stroke or mini-stroke; or if you have or have ever had joint, bone or heart disease.do not breast-feed while taking acitretin or if you have recently stopped taking acitretin.

You should know that acitretin may limit your ability to see at night. This problem may begin suddenly at any time during your treatment. Be very careful when driving at night.plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen.

Do not use sunlamps while taking acitretin. Acitretin may make your skin sensitive to sunlight.if you need to have phototherapy, tell your doctor that you are taking acitretin. You should know that acitretin may dry your eyes and make wearing contact lenses uncomfortable during or after treatment. Remove your contact lenses and call your doctor if this happens.


For female patients: Do not take acitretin if you are pregnant or plan to become pregnant within the next 3 years. Acitretin may harm the fetus. You should not begin taking acitretin until you have taken two pregnancy tests with negative results. You must use two acceptable forms of birth control for 1 month before you begin taking acitretin, during your treatment with acitretin, and for 3 years after treatment. Your doctor will tell you which methods of birth control are acceptable.

You do not need to use two methods of birth control if you have had a hysterectomy (surgery to remove the womb), if your doctor tells you that you have finished menopause (change of life), or if you practice total sexual abstinence. If you plan to use oral contraceptives (birth control pills) while taking acitretin, tell your doctor the name of the pill you will use. Acitretin interferes with the action of microdosed progestin ('minipill') oral contraceptives. Do not use this type of birth control while taking acitretin. If you plan to use hormonal contraceptives (birth control pills, patches, implants, injections, and intrauterine devices), be sure to tell your doctor about all the medications, vitamins, and herbal supplements you are taking. Many medications interfere with the action of hormonal contraceptives. Do not take St. John's wort if you are using any type of hormonal contraceptive. You will need to take pregnancy tests regularly during your treatment with acitretin and for at least 3 years after taking acitretin. Stop taking acitretin and call your doctor immediately if you become pregnant, miss a menstrual period, or have sex without using two forms of birth control. In some cases, your doctor can prescribe emergency contraception ('the morning after pill') to prevent pregnancy.Do not consume foods, drinks, or prescription or nonprescription medications that contain alcohol while taking acitretin and for 2 months after treatment. Alcohol and acitretin combine to form a substance that remains in the blood for a long time and can harm the fetus. Read medication and food labels carefully and ask your doctor or pharmacist if you are not sure whether a medication contains alcohol. Your doctor will give you a Patient Agreement/Informed Consent to read and sign before you begin treatment. Be sure to read this carefully and ask your doctor if you have any questions.

For male patients: A small amount of acitretin is present in the semen of male patients who take this medication. It is not known whether this small amount of medication can harm the fetus. Talk to your doctor about the risks of taking this medication if your partner is pregnant or plans to become pregnant. For male and female patients: Do not donate blood while taking acitretin and for 3 years after treatment. Acitretin may cause liver damage. Tell your doctor if you have or have ever had liver disease. If you experience any of the following symptoms, call your doctor immediately: nausea, vomiting, loss of appetite, pain in the upper right part of the stomach, yellowing of the skin or eyes, or dark urine.

Soriatane Side Effects

Acitretin may cause side effects.

Tell your doctor if any of these symptoms are severe or do not go away:

  • Peeling, dry, itchy, scaling, cracked, blistered, sticky or infected skin
  • Brittle or weak fingernails and toenails
  • Dandruff
  • Sunburn
  • Abnormal skin odor
  • Excessive sweating
  • Hair loss
  • Changes in hair texture
  • Dry eyes
  • Loss of eyebrows or eyelashes
  • Hot flashes or flushing chapped or swollen lips
  • Swollen or bleeding gums
  • Excessive saliva
  • Tongue pain
  • Swelling
  • Blistering mouth swelling or blisters
  • Stomach pain
  • Diarrhea
  • Increased appetite
  • Difficulty falling or staying asleep
  • Sinus infection
  • Runny nose
  • Dry nose
  • Nosebleed
  • Joint pain
  • Tight muscles
  • Changes in taste

Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them call your doctor immediately:

  • Rash
  • Headache
  • Extreme thirst
  • Frequent urination
  • Extreme hunger
  • Blurred vision or weakness
  • Dry mouth
  • Nausea and vomiting
  • Shortness of breath
  • Breath that smells fruity
  • Decreased consciousness pain, swelling, or redness of eyes or eyelids eye pain eyes sensitive to light
  • Swelling of hands, feet, ankles, or lower legs
  • Redness or swelling in one leg only
  • Depression thoughts of hurting or killing yourself
  • Bone, muscle, or back pain
  • Difficulty moving any part of your body
  • Loss of feeling in hands or feet
  • Chest pain
  • Slow or difficult speech tingling in arms and legs
  • Loss of muscle tone
  • Weakness or heaviness in legs
  • Cold, gray, or pale skin
  • Slow or irregular heartbeat
  • Dizziness
  • Fast heartbeat
  • Weakness
  • Shortness of breath
  • Ear pain or ringing

Acitretin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.


What to do in case of overdose?

In case of overdose, call the poison control helpline. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services.

What diet should I follow while taking Soriatane?

Unless your doctor tells you otherwise, continue your normal diet.

What to do if I miss my dose?

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What other information should I know?

  • Keep all appointments with your doctor and the laboratory.
  • Your doctor will order certain lab tests to check your body's response to acitretin.
  • Do not let anyone else take your medication.
  • It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
  • You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.


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A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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