RxConnected Prescription Required
IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
Available 7 Days a Week


Express shipping

May be available upon request

Lowest Price, Guaranteed

match price or beat it by 10% *

Life-Time Free shipping

Find out if you're eligible!

  • Delivery time is between 8-14 business days.
  • Express shipping may be available upon request


Treximet is a prescription drug used to treat migraine headaches. It contains sumatriptan, which constricts blood vessels around the brain and reduces bodily triggers of migraine symptoms like pain, nausea, and sensitivity to light and sound. This medication also contains naproxen, an NSAID that reduces pain and inflammation throughout the body. Treximet is meant to treat migraines that have already begun, and won’t prevent one from happening.

Always follow your doctor’s instructions and use Treximet exactly as prescribed.

  • Take as soon as you notice migraine symptoms.
  • Treximet tablets can be swallowed whole with a full glass of water.
  • If symptoms persist, take a second tablet 2 hours after the first.
  • Don’t take more than 2 tablets in a 24 hour period.


Do not take Treximet within 24 hours of another migraine medication.

Do not use within 14 days of an MAOI drug.

Naproxen can cause bleeding in the stomach or intestines that may be fatal.

Before taking Treximet, inform your doctor if you have any of the following:

  • Stroke, or any heart disease or surgery
  • High blood pressure or circulation problems
  • Wolff-Parkinson-White syndrome
  • Different or unusual headaches
  • Asthma or allergic reaction to NSAIDs
  • Late stage pregnancy or breastfeeding
  • Seizures
  • Liver or kidney disease

Side Effects

Common side effects of Treximet include:

  • Dry mouth, heartburn, nausea
  • Drowsiness, weakness
  • Irregular heartbeat
  • Pain or pressure in throat, tight muscles
  • Numbness or tingling

Contact your doctor if you experience these more serious side effects:

  • Heart attack symptoms – spreading chest pain or pressure, nausea, sweating
  • Numb, tingling or pale blue fingers or toes
  • Severe skin reaction – sore throat, swollen face or tongue, burning eyes, fever, skin pain, red or purple rash with blistering
  • Seizures
  • Anemia – light-headed, short of breath, pale skin, rapid heart rate, trouble concentrating
  • Kidney problems – blood in urine, urinating more or less than usual, swelling, weight gain
  • Liver problems – jaundice, dark urine, upper abdominal pain, itching, fatigue, nausea, light-colored stools
  • Bloody or black stools, coughing or vomiting blood
  • Severe stomach pain and bloody diarrhea, vomiting, weight loss


Will Treximet prevent migraines from occurring?

No. Treximet only treats headaches once they’ve started, and won’t prevent future headaches.

Can I take NSAIDs at the same time as Treximet?

Treximet already contains an NSAID called naproxen. Avoid taking other NSAIDs at the same time.

Hear From People Like You

Don't just take our word, listen to real customers whose lives have changed for the better.

Real People, Trustworthy Reviews

See what others are saying about their experience!

Bernice R

March 23, 2023

I am very pleased with RX Connected. My conversations with everyone there has been positive and I really appreciate your quick response if I have a question.

MaryJean P

October 26, 2022

I really appreciate the reminders when I am due for refills. The staff are efficient and courteous.

Nancy S

October 7, 2022

Your service has been amazing!


October 1, 2022

Considering conditions in parts of the world today delivery was as usual. Meds arrived in the normal amount of time despite traveling distance.


September 14, 2022

The experiences I have had with Rx Connected have always been very positive. The representatives are always polite and clear with the instructions. I especially appreciate the calls I get explaining any delay or change in delivery. Thank you so much.

Joyce W

September 7, 2022

I’m always happy with your service.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

Your Lowest Price, Guaranteed

Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-385-5040 and a member of our CareTeam will be happy to assist you.

Call 1-877-385-5040
* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.