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Treximet is a prescription drug used to treat migraine headaches. It contains sumatriptan, which constricts blood vessels around the brain and reduces bodily triggers of migraine symptoms like pain, nausea, and sensitivity to light and sound. This medication also contains naproxen, an NSAID that reduces pain and inflammation throughout the body. Treximet is meant to treat migraines that have already begun, and won’t prevent one from happening.

Always follow your doctor’s instructions and use Treximet exactly as prescribed.

  • Take as soon as you notice migraine symptoms.
  • Treximet tablets can be swallowed whole with a full glass of water.
  • If symptoms persist, take a second tablet 2 hours after the first.
  • Don’t take more than 2 tablets in a 24 hour period.


Do not take Treximet within 24 hours of another migraine medication.

Do not use within 14 days of an MAOI drug.

Naproxen can cause bleeding in the stomach or intestines that may be fatal.

Before taking Treximet, inform your doctor if you have any of the following:

  • Stroke, or any heart disease or surgery
  • High blood pressure or circulation problems
  • Wolff-Parkinson-White syndrome
  • Different or unusual headaches
  • Asthma or allergic reaction to NSAIDs
  • Late stage pregnancy or breastfeeding
  • Seizures
  • Liver or kidney disease

Side Effects

Common side effects of Treximet include:

  • Dry mouth, heartburn, nausea
  • Drowsiness, weakness
  • Irregular heartbeat
  • Pain or pressure in throat, tight muscles
  • Numbness or tingling

Contact your doctor if you experience these more serious side effects:

  • Heart attack symptoms – spreading chest pain or pressure, nausea, sweating
  • Numb, tingling or pale blue fingers or toes
  • Severe skin reaction – sore throat, swollen face or tongue, burning eyes, fever, skin pain, red or purple rash with blistering
  • Seizures
  • Anemia – light-headed, short of breath, pale skin, rapid heart rate, trouble concentrating
  • Kidney problems – blood in urine, urinating more or less than usual, swelling, weight gain
  • Liver problems – jaundice, dark urine, upper abdominal pain, itching, fatigue, nausea, light-colored stools
  • Bloody or black stools, coughing or vomiting blood
  • Severe stomach pain and bloody diarrhea, vomiting, weight loss


Will Treximet prevent migraines from occurring?

No. Treximet only treats headaches once they’ve started, and won’t prevent future headaches.

Can I take NSAIDs at the same time as Treximet?

Treximet already contains an NSAID called naproxen. Avoid taking other NSAIDs at the same time.

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