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IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
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Buy Vagifem (Estradiol) Online

It has never been simpler to order prescription medications online from Canadian pharmacies. RXConnected lets you buy Vagifem for a fraction of the cost you are used to paying in the US. Order online today or call us 7 days a week to make big savings.

What is Vagifem?

Vagifem is a form of estrogen, a female hormone that regulates many functions in the body. This medication is typically prescribed to treat symptoms of menopause including vaginal dryness, irritation, and hot flashes. These symptoms are a result of the body making less estrogen which is a female sex hormone that regulates many body processes.

Always follow your doctor’s instructions when taking Vagifem. Never change dosage before consulting a healthcare professional.

  • Vagifem comes as individual applicators which are already loaded with tablets inside.
  • Insert the applicator gently into your vagina and press down on the plunger to release the medication.
  • If the Vagifem tablet falls out before it has been used, discard it and use a new applicator.
  • Vagifem should be used regularly. Always follow your dosing schedule.
  • Tell your doctor if your condition worsens or does not improve.


Vagifem may increase your chances of developing endometrial cancer (cancer of the uterus). Watch for unusual bleeding and inform your doctor immediately.

Vagifem may also increase your risk of ovarian cancer, stroke, dementia, and blood clots.

When taken with progestin, estrogen products like Vagifem can cause heart disease, stroke, dementia, blood clots, and breast cancer. These risks may depend on how long you use estrogen, and the products should be used for the least amount of time possible.

Vagifem alone does not appear to increase risk of breast cancer when taken for up to 7 years after menopause.

Have regular physical examinations if you take Vagifem for an extended period of time.

Vagifem should not be used if you are pregnant.

Vagifem Side Effects

Common side effects of Vagifem include:

  • Nausea and vomiting
  • Tender breasts
  • Dizziness and headache
  • Cramps and bloating
  • Changes in libido

More serious side effects of Vagifem include:

  • Abnormal bleeding
  • Heart attack symptoms including chest pain, nausea, shortness of breath
  • Jaundice
  • Pain and swelling of the stomach
  • Breast lump
  • Stroke symptoms including sudden numbness or weakness, problems with vision, speech or balance


What time of day should I use Vagifem?

You can take Vagifem at any time of day that’s convenient for you. Try to take Vagifem at the same time every day.

Will my menopause symptoms go away on their own?

Some menopause symptoms, including hot flashes, are likely to go away on their own. But other symptoms like vaginal dryness may persist due to lack of estrogen. Talk to your doctor about your symptoms and how long you should take Vagifem for.

Can I buy Vagifem over the counter?

No. Vagifem is only available with a prescription at this time.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-385-5040 and a member of our CareTeam will be happy to assist you.

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* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.

Real Customers, Honest Reviews

I have had good experiences with RX Connected. Rich
Richard February 28, 2020

Real Customers, Honest Reviews

I placed my first order last November. The process is exactly as I was told. I emailed my information, and sent original copies to them. Every time I have refilled my medication the representative has been friendly,and knowledgeable. I called today inquiring about the current status of a refill. After a short time, the representative gave me the information I needed (so I wouldn't worry). I appreciate the savings, and the professionalism shown by all the employees I've had contact with via phone. Keep up the good work.
Alex February 27, 2020

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Like most other people, my prescription was very expensive and not covered. I started looking and found this pharmacy. While it takes approximately a month to receive your script, it's worth it for the savings.
Margaret February 26, 2020

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In the past, I had heard people talk about getting some of their prescriptions from Canada due to the high prices in the US. I never really considered it until after a local doctor suggested RX Connected for one of my recommended medications. The price for the medication here was very expensive and not covered by by Medicare drug supplement plan. I'm very grateful that he told me about RX Connected. I have since told several other people about RX Connected. After your doctor writes the initial prescription, you just send it in, and the process begins. They are careful, professional, and send me my medication by mail, on time, like clock-work. Thank you RX Connected!
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