Vagifem may increase your chances of developing endometrial cancer (cancer of the uterus). Watch for unusual bleeding and inform your doctor immediately.
Vagifem may also increase your risk of ovarian cancer, stroke, dementia, and blood clots.
When taken with progestin, estrogen products like Vagifem can cause heart disease, stroke, dementia, blood clots, and breast cancer. These risks may depend on how long you use estrogen, and the products should be used for the least amount of time possible.
Vagifem alone does not appear to increase risk of breast cancer when taken for up to 7 years after menopause.
Have regular physical examinations if you take Vagifem for an extended period of time.