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What is Wellbutrin XL?

Wellbutrin XL (bupropion XL) is an antidepressant drug used to treat major depressive disorder and seasonal affective disorder. It belongs to a unique class of drugs called aminoketones. Wellbutrin XL helps to restore balance of neurotransmitters in the brain, particularly dopamine and norepinephrine.

Always follow your doctor’s instructions and use Wellbutrin XL exactly as prescribed.

• Take Wellbutrin XL with or without food. Taking this medication with or after a meal or snack may reduce stomach upset.
• Swallow Wellbutrin XL tablets whole. Do not break, crush or chew.
• It is typically taken in the morning as taking Wellbutrin XL late in the day may cause sleeping problems.
• It may take four weeks or more to feel the full effect of Wellbutrin XL.

Before taking Wellbutrin XL, inform your doctor if you have any of the following:

• Recently stopped drinking alcohol, taking seizure medications, or sedatives
• Used an MAOI in the last 2 weeks
• Seizures
• Heart disease
• Head, brain, or spinal cord injury
• Diabetes
• Narrow-angle glaucoma
• High blood pressure
• Eating disorders
• Bipolar disorder

Tell your doctor if you are pregnant or breast feeding.

Never stop taking Wellbutrin without your doctor’s guidance. Suddenly stopping Wellbutrin may lead to withdrawal symptoms.

Common side effects of Wellbutrin XL include:

• Dry mouth
• Stuffy nose
• Dizziness
• Joint pain
• Constipation or nausea
• Insomnia

More serious side effects include:

• Seizures or convulsion
• Manic episodes including reckless behavior, extreme mood swings, sleep problems, racing thoughts, increased energy
• Irregular or pounding heartbeat
• Skin reactions: fever, sore throat, swelling, skin pain, red or purple rash, blistering and peeling
• Blurred or tunnel vision, eye pain, halos
• Suicidal thoughts or actions

Can I drink alcohol while taking Wellbutrin XL?

It isn’t recommended that you mix alcohol and Wellbutrin. Doing so may cause dizziness, drowsiness, and blurred vision. You may also experience lower alcohol tolerance, leading to intoxication or alcohol poisoning.

Alcohol is a depressant that may negatively affect your mental health even if it doesn’t interact poorly with your medication.

What if I’m switching from another antidepressant to Wellbutrin XL?

If you’re currently taking an MAOI (Marplan, Nardil, Emsam), you should wait at least 2 weeks between discontinuing your current drug and starting Wellbutrin. Talk to your doctor about how to gradually taper off your current medication.