Zestoretic is a combination medicine used to treat high blood pressure. It contains an ACE inhibitor (lisinopril) that relaxes blood vessels and a diuretic (hydrochlorothiazide) that prevents the body from absorbing too much salt.

Always follow your doctor’s instructions and use Zestoretic exactly as prescribed.

• Take with a full glass of water.
• You may be easily dehydrated while taking Zestoretic. Take care to drink enough water and call your doctor if you have excessive sweating, ongoing vomiting or diarrhea.
• High blood pressure often comes with no symptoms. Continue use even if you feel well.

Don’t use Zestoretic if you are pregnant or breastfeeding.

Do not use Zestoretic if you’re allergic to sulfa drugs, are unable to urinate, or have ever had angioedema.

Wait at least 36 hours between taking Zestoretic and any medicine containing sacubatril.

If you have diabetes, do not take Zestoretic together with medications that contain aliskiren (Tekturna, Tekamlo).

Before taking Zestoretic, inform your doctor if you have any of the following:

• Kidney or liver disease
• Congestive heart failure or heart disease
• Gout
• Glaucoma
• Lupus
• Allergies to sulfa drugs or penicillin
• Asthma or allergies

Common side effects of Zestoretic include:

• Dizziness or tiredness
• Headache
• Cough

Contact your doctor if you experience these more serious side effects:

• Feeling light headed or passing out
• Eye pain or vision problems
• Producing little or no urine
• Drowsiness, weakness, or restlessness
• Fever, mouth sores, trouble swallowing, chills, trouble swallowing
• Jaundice
• Low sodium levels – confusion, headache, weakness, vomiting, loss of coordination, slurred speech
• High potassium – slow heart rate, nausea, weakness, loss of movement
• Low potassium – constipation, muscle weakness, leg cramps, numbness, tingling, increased thirst and urination, fluttering in chest.

Can I drink alcohol while taking Zestoretic?

Drinking alcohol can lower your blood pressure, and may increase side effects of Zestoretic like dizziness and tiredness. Use alcohol carefully and inform your doctor of any adverse effects.