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Zyprexa is an antipsychotic drug used to treat symptoms of schizophrenia and bipolar disorder. It may be used on its own or together with other antipsychotics or antidepressant medications.

Always follow your doctor’s instructions and use Zyprexa exactly as prescribed.

  • Take with or without food.


Zyprexa may increase risk of death in patients with dementia, and is not approved for use in these cases.

Long-term use can cause a movement disorder involving uncontrollable muscle movements. This may not be reversible, and is more likely to develop the longer you take Zyprexa.

Zyprexa may cause problems during pregnancy. Talk to your doctor if you become pregnant.

Avoid drinking alcohol while on Zyprexa.

Before taking Zyprexa, inform your doctor if you have any of the following:

  • Liver disease
  • Heart disease, heart failure, heart attack, or stroke
  • High cholesterol
  • High or low blood pressure
  • Diabetes
  • Seizures
  • Enlarged prostate
  • Glaucoma
  • Bowel problems

Side Effects

Common side effects of Zyprexa include:

  • Increased appetite and weight gain
  • Headache, drowsiness, dizziness
  • Stomach pain, constipation
  • Tremors, shaking, numbness
  • Pain in arms and legs
  • Dry mouth or increased salivation

Contact your doctor if you experience these more serious side effects:

  • Liver problems – jaundice, dark urine, upper abdominal pain, itching, fatigue, nausea, light-colored stools
  • Swollen hands or feet
  • Nervous system reaction – high fever, stiff muscles, rapid or uneven heartbeat, sweating, confusion, tremors
  • Dehydration – heavy sweating, hot or dry skin, extreme thirst, unable to urinate
  • Confusion, hallucinations, suicidal thoughts, unusual behavior
  • Difficulty speaking or swallowing
  • Sudden weakness or illness including flu and cold symptoms
  • High blood sugar – weight loss, increased thirst and urination, hunger, drowsiness, blurred vision


How can I manage weight gain while on Zyprexa?

Increased physical activity and commitment to a healthy diet can help minimize weight gain while on Zyprexa. Have your weight monitored regularly by your doctor.

Can I stop taking Zyprexa if I’m feeling better?

Suddenly stopping Zyprexa can cause unpleasant withdrawal symptoms. If you wish to discontinue or try a different medication, talk to your doctor about gradually tapering off.

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