Eliquis is a prescription anticoagulant, commonly called a blood thinner. Anticoagulants help prevent and treat blood clots.

In adults, Eliquis is prescribed to:

• Lower the risk of stroke and blood clots in people with non-valvular atrial fibrillation, which is an irregular heartbeat not caused by a heart valve problem
• Prevent blood clots in the legs, known as deep vein thrombosis, and in the lungs, known as pulmonary embolism, after hip or knee replacement surgery
• Treat existing deep vein thrombosis or pulmonary embolism
• Reduce the risk of deep vein thrombosis or pulmonary embolism from occurring again after initial treatment for a blood clot

For more details on Eliquis, including how it works and what it treats, see our detailed Eliquis guide. 

Is generic Eliquis available?

Yes. The generic version of Eliquis is called apixaban.

Although apixaban has FDA approval, it is not yet widely available at U.S. retail pharmacies due to brand-name patent protections. Based on current court rulings, generic apixaban is expected to launch in the United States no earlier than April 1, 2028.

Outside the United States, patent timelines and drug pricing regulations are different. Because of this, generic apixaban is already legally available in Canada and other international markets.

Patients with a valid prescription can order generic apixaban through RxConnected, giving access to the same active ingredient found in Eliquis at a much lower cost while U.S. availability remains delayed.

Eliquis pricing varies substantially depending on where the medication is purchased and whether brand-name or generic options are used.

In the United States, prescription drug prices are not regulated. As a result, U.S. retail pharmacies can charge more than $6.00 per tablet for Eliquis 5 mg. For patients without insurance, this often translates into monthly costs in the hundreds of dollars.

Ordering from an online Canadian pharmacy, such as RxConnected, can reduce the per-tablet cost for both brand-name Eliquis and generic apixaban.

Brand-Name Eliquis 5 mg Price (RxConnected)

Generic Apixaban 5 mg Price (RxConnected)

Even at smaller quantities, RxConnected pricing is significantly lower than typical U.S. retail pharmacy prices. Generic apixaban offers the lowest per-tablet cost while containing the same active ingredient as brand-name Eliquis.

Eliquis Price in the U.S. vs. Canada

Eliquis prices are typically highest at U.S. retail pharmacies and substantially lower when ordered through online Canadian pharmacies. 

Eliquis 5 mg Price in Canada vs. the U.S.

For a detailed breakdown of Eliquis prices and savings options, visit our guide on navigating the cost of Eliquis in the U.S.

Patients with a valid prescription can order Eliquis or generic apixaban through RxConnected by following these steps:

• Go to RxConnected and search for Eliquis or apixaban using the search bar.
• Choose your prescribed dosage and select the quantity you need, then click Add to Cart and proceed to checkout.
• Sign in to your existing account or create a new one. If you prefer to order by phone, you may call 1-877-385-5040.
• Upload your valid prescription during checkout or request that RxConnected contact your doctor or pharmacy on your behalf.
• Review and confirm your order details, then submit your request.
• Once approved, your medication is shipped directly to your home.

How to take Eliquis

Eliquis and generic apixaban should be taken exactly as prescribed by your healthcare provider.

• Take Eliquis by mouth twice daily, about 12 hours apart
• Take doses at the same time each day
• Tablets may be crushed and mixed with water, apple juice, or applesauce if swallowing is difficult

If you miss a dose:

• Take it as soon as possible if only a few hours have passed
• Skip it if it is close to your next scheduled dose
• Do not take two doses at the same time

Your doctor will prescribe the appropriate dose based on your condition and individual health factors. FDA-recommended dosing includes:

• Atrial fibrillation: 5 mg taken twice daily. Some patients may be prescribed 2.5 mg twice daily based on age, weight, or other clinical considerations
• Prevention of deep vein thrombosis or pulmonary embolism after hip or knee replacement surgery: 2.5 mg taken twice daily
• Treatment of deep vein thrombosis or pulmonary embolism: 10 mg taken twice daily for the first 7 days, followed by 5 mg taken twice daily for at least 3 months

Do not stop taking Eliquis or change your dose without medical advice, as this may increase the risk of blood clots or stroke.

Eliquis side effects

The most common side effects of Eliquis are related to bleeding. In many cases, bleeding is mild and resolves without treatment.

Common mild bleeding effects may include:

• Nosebleeds
• Bleeding gums
• Easy bruising

Serious bleeding requires immediate medical attention. Contact a healthcare provider if you experience:

• Unusual weakness, extreme fatigue, pale skin, shortness of breath, or chest discomfort
• Black or tar-like stools, or stools that contain blood
• Bleeding from the rectum
• Urine that appears pink, red, or dark brown
• Heavy or prolonged menstrual bleeding
• Coughing up blood or vomiting material that looks like blood
• Bleeding that does not stop
• Bleeding or injury after trauma, such as a head injury, broken bone, car accident, or sports injury

How much is Eliquis?

Eliquis 5 mg typically costs over $6.00 per tablet at U.S. retail pharmacies without insurance. Through RxConnected, brand-name Eliquis 5 mg costs about $1.39 to $1.91 per tablet, depending on quantity ordered. Generic apixaban costs about $1.08 to $1.50 per tablet and is available in Canada, while U.S. retail availability remains limited due to patent protections.

What is the cheapest place to buy Eliquis 5 mg?

For patients without insurance, the lowest per-tablet prices for Eliquis 5 mg are available through online Canadian pharmacies such as RxConnected. Ordering larger quantities further reduces the cost. Choosing generic apixaban can lower the price even more.

What is the price of Eliquis 5 mg?

At U.S. retail pharmacies: Eliquis 5 mg can cost over $6.00 per tablet without insurance.

Through RxConnected: Brand-name Eliquis 5 mg is available at $1.91 per tablet for a 56-tablet supply and as low as $1.39 per tablet when ordered in bulk.

How much does generic Eliquis cost in Canada?

Generic Eliquis, also called apixaban, costs between $1.08 to $1.50 per tablet in Canada when ordered through RxConnected. A 60-tablet supply averages about $1.50 per tablet, while larger quantities, such as 180 tablets, lower the price to around $1.08 per tablet. 

Generic apixaban contains the same active ingredient as brand-name Eliquis and is legally available in Canada, while U.S. retail availability remains delayed due to patent protections. 

Can I save by choosing generic Eliquis?

Yes, choosing generic Eliquis is the best way to save. While RxConnected offers significant discounts on brand-name Eliquis, the generic version is more affordable. 

Generic Eliquis is called apixaban, and it uses the same active ingredients to achieve the same therapeutic effects. It is also available in the same dosage strengths as the branded version.

Can I save on Eliquis by ordering in bulk?

Yes. Ordering a larger quantity reduces the per tablet cost for both brand-name Eliquis and generic apixaban.

For example, generic apixaban 5 mg costs about $1.50 per tablet when ordering 60 tablets and drops to about $1.08 per tablet when ordering 180 tablets.

Is Eliquis covered by my Medicare insurance coverage?

Eliquis is commonly covered under Medicare Part D plans, but coverage and copays vary. Some patients find that ordering Eliquis through a Canadian pharmacy results in lower out-of-pocket costs than using insurance. 

Are there cheaper alternatives to Eliquis?

Yes, cheaper blood thinners, like warfarin, are available. However, it is important to discuss alternative treatments with your doctor. Eliquis is a newer medication that comes with more benefits and fewer side effects compared to traditional anticoagulants. For many patients, Eliquis is worth the higher price tag. One of the main advantages of Eliquis is that it does not require frequent monitoring. Eliquis also has fewer interactions, giving you more freedom.

How can I save on my Eliquis prescription?

The most effective way to save on Eliquis is to order through an online Canadian pharmacy such as RxConnected. While insurance, coupons, or alternative blood thinners may provide limited savings, Canadian pricing allows access to brand-name Eliquis and generic apixaban at a fraction of U.S. retail pharmacy costs.

What foods should be avoided when taking Eliquis?

Eliquis has fewer food interactions than older blood thinners, but certain fruits can affect how apixaban is processed in the body. Grapefruit, pomelos, and Seville oranges should be avoided. Patients who regularly consume these fruits should discuss their intake with a healthcare provider.

How long does it take for Eliquis to work?

Eliquis begins working within 1 to 3 hours after a dose and reaches peak levels in the body within 3 to 4 hours.

Can I drink alcohol when taking Eliquis?

Alcohol can increase bleeding risk when combined with Eliquis because both have blood-thinning effects. Drinking alcohol while taking Eliquis may raise the chance of serious bleeding or injury. Limiting alcohol intake can help reduce the risk of falls, trauma, and bleeding complications.

How long does Eliquis stay in your system?

Eliquis has a half-life of about 12 hours. In most people, this means Eliquis is largely cleared from the body within 2 to 3 days after the last dose, although this can vary based on overall health. 

Do I need to stop taking Eliquis before surgery?

Yes, you may need to stop taking Eliquis before surgery or medical procedures to reduce bleeding risk. Doctors commonly recommend stopping Eliquis 1 to 2 days before a procedure, depending on the type of surgery and individual health factors. Always follow your healthcare provider’s instructions and do not stop Eliquis without medical guidance. For more information on managing Eliquis before medical procedures, see our guide on what you need to know about Eliquis and surgery.