How to Take Rybelsus

Wednesday 22 November 2023
5 minute(s) read

Table of Contents

I. How Does Rybelsus Work?

II. How To Take Rybelsus

III. Rybelsus Dosages

IV. How to Store Rybelsus

V. Rybelsus Side Effects

VI.Rybelsus Drug Interactions

VII. Final Tips

If you have been prescribed Rybelsus to manage type 2 diabetes, it is essential to understand how to take Rybelsus correctly. In this comprehensive guide, we will simplify the process of taking Rybelsus, the dosages you can expect, and offer tips to ensure your treatment goes smoothly. 

How Does Rybelsus Work?

Rybelsus is an FDA-approved medication that lowers 24-hour glucose concentration by an impressive 22% when combined with a healthy diet and exercise. [1]

The active ingredient in Rybelsus is semaglutide, which falls under the category of GLP-1 receptor agonists. This group shares a 94% resemblance to a natural hormone in our body that controls blood sugar levels (called GLP-1). [1]

My mimicking GLP-1, Rybelsus decreases blood sugar levels by:

  • Increasing insulin release from the pancreas after a meal: This helps lower blood sugar levels and decreases appetite.
  • Decreasing glucagon release from the liver: This prevents your liver from making and releasing too much sugar.
  • Slowing down stomach emptying: This prolongs feelings of fullness after a meal. [1]

a woman stretching

How To Take Rybelsus

To optimize the benefits of Rybelsus, it is essential to follow the dosing instructions strictly. Luckily, these are easy to implement.

First, take Rybelsus on an empty stomach and at least 30 minutes before other oral medications, food, or drink. This ensures optimal absorption and prevents any potential interactions with other medications. [2]

Secondly, when it is time to take Rybelsus, swallow the tablets whole with a maximum of 4 ounces (118 mL) of water. [2] Crushing or chewing the tablets can alter the way your body absorbs the medication and can lead to overdosing or an ineffective dose. [3]

Lastly, if you miss a dose, skip it and continue with your regular schedule the following day. [2]

Rybelsus Dosages

Your physician will prescribe Rybelsus in gradually increasing dosages when you begin treatment. By starting with a small dosage, your body can adapt to the medication before you begin the standard treatment dose. [2]

Initially, your physician will prescribe a 3 mg dose once daily for 30 days. This dose is not powerful enough to control your blood sugar, but it gives your body a chance to get used to the medication. [2]

If you respond well to the 3 mg dose, your physician will increase your dosage to 7 mg once daily for another 30 days. This dose can effectively control blood sugar levels in most individuals but may not be sufficient for everyone. [2]

If the 7 mg dose does not effectively manage your blood sugar, your physician may recommend a maximum dose of 14 mg once daily. This is the most potent Rybelsus dosage. [2]

Please note that these dosages are a guideline by Rybelsus and the FDA. Your healthcare provider may tailor them to your unique medical history and needs.

a woman taking a pill

How to Store Rybelsus

Proper storage is essential to maintain the effectiveness of Rybelsus. Keep the tablets in the Rybelsus bottle until you're ready to take them. The blue cap on the bottle is designed to protect the tablets. [2]

We strongly advise against storing Rybelsus tablets in a pill organizer as it may decrease the effectiveness of the tablets. Instead, use the easy tracking system designed by Rybelsus to track your daily dosage (found on page 7). [2]

By following these instructions, you ensure the medication remains intact and functions as intended.

Rybelsus Side Effects

Like any medication, Rybelsus may lead to side effects. These can include:

  • Diarrhea
  • Abdominal pain
  • Decreased appetite
  • Nausea
  • Constipation
  • Vomiting [2]

If you experience nausea when starting Rybelsus, consider these helpful tips:

  • Drink ice-cold or clear drinks
  • Eat smaller, more frequent meals
  • Avoid greasy food
  • Eat light and bland foods (ex. saltines, plain bread) [2]

Rybelsus Drug Interactions

Before starting Rybelsus, it is crucial to inform your doctor about all your current medications. This includes over-the-counter drugs, prescription medications, herbal remedies, and supplements. Some medications may interact with Rybelsus, potentially decreasing the effectiveness of either medication.

Interactions With Oral Medications

Since Rybelsus slows down stomach emptying, it can affect the absorption of oral medications. To mitigate this, ensure you take Rybelsus on an empty stomach and wait at least 30 minutes before taking any other oral medications. [1] For more information, see the section “How to Take Rybelsus.”

Additionally, inform your doctor of any oral medications you are taking. Your physician may need to monitor your progress more closely to ensure all medications work effectively in your treatment. [1]

Insulin Interaction

Since insulin and Rybelsus both control blood sugar, combining these medications can lead to low blood sugar (hypoglycemia). This occurs when your blood sugar drops below 70 mg/dL. [4] To prevent this, your doctor may adjust your insulin dose while you are taking Rybelsus. [1]

Hypoglycemia can be dangerous if left untreated. In addition to regularly monitoring your blood sugar, it is also important to recognize the symptoms:

  • Shaking
  • Sweating
  • Anxiety or nervousness
  • Confusion or irritability
  • Hunger
  • Fast heartbeat
  • Dizziness [4]

a happy woman

Final Tips

Rybelsus is an effective tool in the management of type 2 diabetes, but it is essential to stay active in your treatment to maximize the benefits. Here are some easy tips you can implement:

First, add daily activity and healthy food to your routine. Rybelsus operates best when complemented by healthy lifestyle changes. [2] These don't have to be monumental shifts; even small, everyday changes can be beneficial.

Secondly, keep a close eye on your blood sugar levels and keep the communication flowing with your doctor. This is especially important if you are taking both Rybelsus and insulin, as the combination might lead to low blood sugar (hypoglycemia). [2] While hypoglycemia symptoms are often noticeable, there are times when it can catch you off guard. [4] Regularly monitoring your blood sugar levels acts as your safety net, ensuring your levels remain stable. For further details on insulin interaction and recognizing hypoglycemia symptoms, refer to the "Rybelsus Drug Interactions" section in this article.

Rybelsus is an effective treatment for type 2 diabetes when used properly. To order Rybelsus at an affordable price point, choose a reputable online Canadian pharmacy like RxConnected to fill your prescription.

DISCLAIMER: The content in this article is intended for informational purposes only. This website does not provide medical advice. In all circumstances, you should always seek the advice of your physician and/or other qualified health professionals(s) for drug, medical condition, or treatment advice. The content provided on this website is not a substitute for professional medical advice, diagnosis or treatment.