What's More Effective? Rybelsus vs Ozempic

Tuesday 14 November 2023
5 minute(s) read

Table of Contents

I. Rybelsus vs Ozempic: How Do They Work?

II. Rybelsus vs Ozempic: Dosage and Administration

III. Final Verdict

IV. Other Diabetes Medications

V. Consult Your Healthcare Provider

Selecting the appropriate medication for type 2 diabetes is a complex decision influenced by various factors, such as your health profile and personal preferences. Given the number of medications in the market today, it can be a difficult choice.

This article will analyze the effectiveness of two popular diabetes medications: Rybelsus and Ozempic. To begin, we'll dive into their mechanisms of action, dosage requirements, and administration methods. We will then discuss which medication is the most effective for you.

Rybelsus vs Ozempic: How Do They Work?

Both medications work the same way and are FDA-approved for treating type 2 diabetes. [1] [2]

Rybelsus and Ozempic are semaglutides and fall under the category of GLP-1 receptor agonists. Both medications mimic GLP-1, a natural hormone produced in the body to control blood sugar levels. Drugs that imitate GLP-1 help decrease blood sugar levels by:

  • Stimulating insulin release from the pancreas when blood sugar levels are high.
  • Inhibiting the liver from making and releasing too much sugar.
  • Decreasing the rate that food leaves the stomach, helping you feel full for longer. [3] [4]

It’s important to note that while both medications can lead to weight loss, neither is FDA-approved as a weight loss treatment. In addition, to achieve optimal results, it’s essential to incorporate a healthy diet and exercise alongside the medications. [1] [2]

a doctor helping the patient make a decision

Rybelsus vs Ozempic: Dosage and Administration

The difference between Ozempic and Rybelsus lies in their dosage and administration. Rybelsus is a once-daily oral tablet [5] whereas Ozempic is a once-weekly subcutaneous injection. [6]

Rybelsus Dosage

When beginning Rybelsus, your healthcare provider will slowly increase the dose over a few months. This approach allows your body to acclimate to the new medication. [5]

Initially, you'll receive a prescription for a 3 mg dosage once daily for the first 30 days. This dose is a gentle introduction to Rybelsus and is not potent enough to regulate your blood sugar levels effectively. [5]

Following this period, the dosage is raised to 7 mg once daily for another 30 days. While this dose aids in glycemic control, it might not be strong enough for everyone. If further control is necessary, your doctor will adjust your dosage to 14 mg once daily. [5]

Ozempic Dosage

Similar to Rybelsus, Ozempic is prescribed in gradually increasing dosages. This allows your body to adjust to the new medication. [6]

Initially, you'll be prescribed 0.25 mg injected once weekly for the first four weeks. This introductory dose allows your body to acclimate to Ozempic. The dose is then increased to 0.5 mg once weekly for four weeks. If this dose isn't sufficient for blood sugar control, the dosage is further increased to 1 mg once weekly for four weeks. If additional help is still needed, the dose can be increased to a maximum of 2 mg once weekly. [6]

a doctor showing the patient certain options about their treatment

Final Verdict

Now, the crucial question: which is more effective, Rybelsus or Ozempic?


Rybelsus and Ozempic are both semaglutides. Studies have shown that semaglutides can decrease 24-hour glucose concentration by an impressive 22% when used alongside a healthy diet and exercise. [1] Additional studies have found that oral and injectable semaglutides result in similar weight loss. [7]


Rybelsus takes a significant lead in this aspect. The oral form eliminates the need for injections, a significant concern for many patients. Taking a pill is generally more convenient and less intimidating than giving yourself a weekly shot.


The weekly injection of Ozempic may ensure better adherence in some patients as they only need to remember it once a week. In contrast, Rybelsus must be taken daily, which could lead to adherence issues for some individuals.

Personal Preferences

Ultimately, the choice between Rybelsus and Ozempic comes down to personal preferences. Some may prioritize the convenience of an oral pill, while others may find the weekly injection of Ozempic more manageable.

a person dispensing medication from a container

Other Diabetes Medications

In addition to semaglutides like Rybelsus and Ozempic, other classes of diabetes medications may be more suitable for your situation. In this section, we'll discuss two options: Jardiance and Metformin.


Jardiance is an FDA-approved oral medication for

  • Treating type 2 diabetes
  • Reducing the risk of cardiovascular death and hospitalization in individuals with type 2 diabetes or cardiovascular disease [8]

It belongs to a class of medications called SGLT2 inhibitors. These drugs facilitate glucose excretion through the urine by reducing kidney reabsorption. [8]

Jardiance is available in 10 mg and 25 mg tablets. The dosage is determined in collaboration with your doctor. [8]


Metformin is typically the first medication prescribed for type 2 diabetes due to its effectiveness and tolerability by most patients. [9]

Metformin controls blood sugar levels by decreasing the liver’s glucose production and increasing insulin sensitivity in muscle cells. [10]

Consult Your Healthcare Provider

Both Rybelsus and Ozempic are effective options for managing type 2 diabetes. Rybelsus offers the option of an oral pill, whereas Ozempic provides the convenience of a once-weekly injection. 

The choice between them should be made with your healthcare provider's guidance. The effectiveness of medications can vary from person to person based on their unique health profiles and treatment plans. Your doctor will consider your medical history, lifestyle, and personal preferences when determining which medication suits you.

Remember, managing diabetes is a partnership between you and your healthcare team. At RxConnected, we want to help you make the best choice for your health.

If you're ready to purchase Rybelsus, visit the medication page for pricing information.

DISCLAIMER: The content in this article is intended for informational purposes only. This website does not provide medical advice. In all circumstances, you should always seek the advice of your physician and/or other qualified health professionals(s) for drug, medical condition, or treatment advice. The content provided on this website is not a substitute for professional medical advice, diagnosis or treatment.